In partnership with the State of New York, the Office of the Staten Island Borough President, Northwell Health, the Columbia University Mailman School of Public Health and the Columbia University School of Engineering, the Consortium for Affordable Medical Technologies (CAMTech) will host an Empire State Opioid Epidemic Innovation Challenge for a diverse community to co-create solutions that have the potential to change the trajectory of the local and national opioid crisis. The Innovation Challenge is comprised of two events. First, on Sept. 28, the Challenge Summit will convene clinicians, government representatives, public health experts and affected community members to facilitate a discussion of challenges and provide critical insight into the opioid epidemic. Importantly, this day serves as the unmet needs identification in the opioid crisis to inform solutions designed and built over the weekend. Following the Challenge Summit on Sept. 29-30, the Solutions Sprint will serve as an open-innovation platform for a diverse community to co-create solutions over a 48-hour period.